Discovering Disease Subtypes that Improve Treatment Predictions: Interpretable Machine Learning for Personalized Medicine

31 Jan
Wednesday, 01/31/2018 4:00pm to 5:00pm
Computer Science Building, Room 151
Seminar
Speaker: Michael Hughes

Abstract:  For complex diseases like depression, choosing a successful treatment from several possible drugs remains a trial-and-error process in current clinical practice. By applying statistical machine learning to the electronic health records of thousands of patients, can we discover subtypes of disease which both improve population-wide understanding and improve patient-specific drug recommendations?

One popular approach is to represent noisy, high-dimensional health records as mixtures of low-dimensional subtypes via a probabilistic topic model. I will introduce this common dimensionality reduction method and explain how off-the-shelf topic models are misspecified for downstream prediction tasks across many domains from text analysis to healthcare. To overcome these poor predictions, I will introduce a new framework -- prediction-constrained training -- which learns interpretable topic models that offer competitive drug recommendations. I will also discuss open challenges in using machine learning to improve clinical decision-making.

 

Reception at 3:30 for attendees in CS150

Faculty Host
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